Immunological aspects of age-related diseases

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Immunological aspects of age-related diseases

The proportion of elderly people rises in the developed countries. The increased susceptibility of the elderly to infectious diseases is caused by immune dysfunction, especially T cell functional decline. Age-related hematopoietic stem cells deviate from lymphoid lineage to myeloid lineage. Thymus shrinks early in life, which is followed by the decline of naïve T cells. T-cell receptor repertoi...

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Clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. This attitude is no longer acceptable. Surge of information and discoveries in neurosciences within the last two decades translated into therapeutic interventions which is literally life saving in some o...

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Clinical immunological and immunogenetical aspects of neurological diseases.

The anti-tumor response of human invariant NKT (NKT) cells is well established. A novel T cell subset, mucosal-associated invariant T (MAIT) cells, possesses similar regulatory properties to NKT cells in autoimmune models and disease. Here, we examined the clonality of four T cell subsets expressing invariant aTCR, including Va7.2-Ja33 of MAIT cells, in 19 kidney and brain tumors. The MAIT clon...

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ژورنال

عنوان ژورنال: World Journal of Biological Chemistry

سال: 2017

ISSN: 1949-8454

DOI: 10.4331/wjbc.v8.i2.129